The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3', 5'-cyclic monophosphate in platelets. Regulation by cyclic AMP and prostaglandin E 1. Thromb Haemostas 1980 42: 1580-1588Īggregation of blood platelets by adenosine diphosphate and its reversal. Biochem Pharmacol 1980 29: 1799-1805ĪTP- and ADP-induced rat platelet aggregation: significance of plasma in ATP-induced aggregation. Molec Pharmacol 1977 13: 400-406Įffects of adenosine analogs and adenine nucleotides on adenosine 5'-diphosphate-induced rat platelet aggregation. Selective inhibition of separated forms of human platelet cyclic nucleotide phosphodiesterase by platelet aggregation inhibitors. Biochem Pharmacol 1979 28: 501-510ĥ'-methylthioadenosine and 2',5'-dideoxyadenosine blockade of the inhibitory effects of adenosine on ADP-induced platelet aggregation by different mechanisms. Significance of alterations in the nucleotide pools. Biochem Pharmacol 1975 24: 2239-2248Īdenosine analogs and human platelets II: inhibition of ADP-induced aggregation by car-bocyclic adenosine and imidazole-ring modified analogs. Biochem Pharmacol 1975 24: 693-701Īdenosine analogs and human platelets: effects on nucleotide pools and the aggregation phenomenon. Can J Biochem 1971 49: 262-270Īdenosine deaminase from human erythrocytes: purification and effects of adenosine analogs.
A Mediated process in human erythrocytes. Identification of the antiplatelet substance in Chinese black tree fungus. These findings indicate that Mo-er extracts contain an agent (or agents) in addition to Ado, that blocks platelet aggregation by a mechanism that does not involve the platelet cyclic AMP system. This inhibition is not reversed by either DDA or MTA. ADP-induced rat platelet aggregation is strongly inhibited by Mo-er extracts, but not by Ado. The inhibition of platelet aggregation is only partially blocked by 2’,5’-dideoxy-adenosine (DDA), an inhibitor of platelet adenylate cyclase and 5’-deoxy, 5’-methylthioadenosine (MTA), an antagonist of Ado receptors. The inhibitory effects of Mo-er extracts on ADP-induced human platelet aggregation are greatly potentiated by the inhibitors of cyclic AMP phosphodiesterase such as oxagrelate (phthalazinol) and papaverine. Furthermore, Mo-er extract treated with adenosine deaminase to degrade the Ado retained the capacity to inhibit platelet aggregation. Mo-er extracts caused a more rapid onset and a longer duration of inhibition than produced by equivalent amounts of Ado. The inhibition of ADP-induced platelet aggregation by Mo-er extracts and by Ado was compared. HPLC analysis of two varieties of Mo-er, A.auricula and A.polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 micrograms per gram of dry fungus, respectively.
Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation.
Auricularia auricula extract pdf#
PDF Download Buy Article Permissions and Reprints Summary
0 kommentar(er)
